This website includes images from past winners of FASEB's Annual BioArt Competition. Each day, scientific investigators produce thousands of images and videos as a part of their research; however, only a few are ever seen outside of the laboratory. Through the BioArt competition, FASEB aims to share the beauty and breadth of biological research with the public. For more information, visit the BioArt website.
Experimental Biology thanks Heinz Baumann, Paul R. Odgren, and Randee Young for allowing EB 2018 to feature their winning images. Below you can find more information about each BioArt image.
Heinz Baumann*, Sean T. Glenn†, Mary Kay Ellsworth, and Kenneth W. Gross‡
Roswell Park Cancer Institute, Buffalo, NY
Research Focus: Pancreatic cancer
When multiple tumors or cancers have spread throughout the body, distinguishing which cell came from which tumor can be difficult. To overcome this challenge, this research team used “confetti” fluorescent labeling in their mouse model of pancreatic cancer. In this proof of concept image, adult mouse cells were induced to randomly make one of four different fluorescent molecules. The descendants of these cells continue to produce the same color as their parent cell. The NIH National Cancer Institute and National Institute of Diabetes and Digestive and Kidney Diseases fund this research project, which seeks to identify genetic changes that contribute to pancreatic cancer.
*American Society for Biochemistry and Molecular Biology
†Association of Biomolecular Resource Facilities
‡American Physiological Society
Paul R. Odgren*
University of Massachusetts Medical School, Worcester, MA
Research Focus: Bone development and healing
During normal bone development and fracture healing, cartilage is transformed into bone. Osteoclasts, a specialized type of cell, eat the cartilage, creating a passageway for blood vessels, marrow, and other bone cells. In this image of cartilage (purple and white) from a young mouse femur, osteoclasts (red) surround a blood vessel filled with red blood cells (yellow). In contrast to normal osteoclasts, the cells seen here have only a single nucleus due to the lack of gene involved in osteoclast development. Funding from the NIH National Institute of Arthritis and Musculoskeletal and Skin Diseases supports this research program that aims to understand how large, bone resorbing osteoclasts form, and whether preventing them from fusing together is a way to control bone loss in osteoporosis, arthritis, or other conditions.
* The American Society for Bone and Mineral Research
Randee Young and Xin Sun*
University of Wisconsin–Madison (Madison, WI)
Research Focus: Lung development
C-shaped rings of cartilage (red) give the trachea, or windpipe, its shape and strength. Because all oxygen that reaches the lungs must first pass through the trachea, its structural integrity is essential to human life. In conditions like tracheomalacia, malformation of the cartilage weakens the trachea, leading to airway collapse. The NIH National Heart, Lung and Blood Institute supports this research project on identifying the signals that prompt developing cartilage to segment into C-shaped rings. This image from a mouse is helping the investigators examine the organization of nerve cells (green) and their potential role in directing cartilage (red) formation.
* Society for Developmental Biology and Genetics Society of America